Neonatal stress modulates sickness behavior: role for proinflammatory cytokines.
Identifieur interne : 001072 ( Main/Exploration ); précédent : 001071; suivant : 001073Neonatal stress modulates sickness behavior: role for proinflammatory cytokines.
Auteurs : Ronit Avitsur [Israël] ; Rachel Maayan ; Abraham WeizmanSource :
- Journal of neuroimmunology [ 1872-8421 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Animaux nouveau-nés, Comportement de maladie (physiologie), Cytokines (physiologie), Femelle, Marqueurs biologiques (métabolisme), Mâle, Médiateurs de l'inflammation (physiologie), Souris, Souris de lignée C57BL, Stress psychologique (immunologie), Stress psychologique (psychologie), Séparation d'avec la mère.
- MESH :
- immunologie : Stress psychologique.
- métabolisme : Marqueurs biologiques.
- physiologie : Comportement de maladie, Cytokines, Médiateurs de l'inflammation.
- psychologie : Stress psychologique.
- Animaux, Animaux nouveau-nés, Femelle, Mâle, Souris, Souris de lignée C57BL, Séparation d'avec la mère.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Biomarkers.
- chemical , physiology : Cytokines, Inflammation Mediators.
- immunology : Stress, Psychological.
- physiology : Illness Behavior.
- psychology : Stress, Psychological.
- Animals, Animals, Newborn, Female, Male, Maternal Deprivation, Mice, Mice, Inbred C57BL.
Abstract
Neonatal stress increased the duration and augmented symptoms of sickness behavior induced by influenza virus infection or endotoxin challenge in mice. Since proinflammatory cytokines were implicated in sickness behavior, the present study sought to determine the effect of neonatal stress on cytokines-induced sickness behavior and on proinflammatory cytokine secretion. Data indicate that separation of mouse pups from the dams at an early age (maternal separation, MSP) increased the duration and augmented some of the symptoms of sickness behavior induced by proinflammatory cytokines. In addition, MSP partially suppressed cytokine and corticosterone secretion in response to endotoxin administration. These data may suggest that MSP increased sensitivity to the effects of proinflammatory cytokines on sickness behavior following an immune challenge.
DOI: 10.1016/j.jneuroim.2013.02.009
PubMed: 23489747
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Neonatal stress increased the duration and augmented symptoms of sickness behavior induced by influenza virus infection or endotoxin challenge in mice. Since proinflammatory cytokines were implicated in sickness behavior, the present study sought to determine the effect of neonatal stress on cytokines-induced sickness behavior and on proinflammatory cytokine secretion. Data indicate that separation of mouse pups from the dams at an early age (maternal separation, MSP) increased the duration and augmented some of the symptoms of sickness behavior induced by proinflammatory cytokines. In addition, MSP partially suppressed cytokine and corticosterone secretion in response to endotoxin administration. These data may suggest that MSP increased sensitivity to the effects of proinflammatory cytokines on sickness behavior following an immune challenge.</div>
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<country name="Israël"><noRegion><name sortKey="Avitsur, Ronit" sort="Avitsur, Ronit" uniqKey="Avitsur R" first="Ronit" last="Avitsur">Ronit Avitsur</name>
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